• Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go 

      Kvarstein, Gunnvald; Lundeland, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
    • Children's fear of needle injections: A qualitative study of training sessions for children with rheumatic diseases before home administration 

      Sørensen, Kari; Skirbekk, Helge; Kvarstein, Gunnvald; Wøien, Hilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-07)
      <i>Background</i>: Treatment of rheumatic diseases in children often includes long-term needle injections, which represent a risk for refusing medication based on potential needle-fear. How nurses manage children’s fear and pain during the initial educational training session of subcutaneous injections, may affect the management of the subsequent injections in the home settings. The aim of this study ...
    • Cryoneurolysis for cervicogenic headache - A double blinded randomized controlled study 

      Kvarstein, Gunnvald; Högström, Henrik; Allen, Sara Maria; Rosland, Jan Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-13)
      Background and aims - Cervicogenic headache (CEH) is a debilitating condition and analgesics have limited effect. Percutaneous cryoneurolysis is thus still in use although the clinical evidence is lacking. We present a randomized, controlled study to assess the clinical efficacy of cryoneurolysis compared with a corticosteroid combined with a local anaesthetic. <p> <p>Methods - In a university-based ...
    • The efficacy of botulinum toxin A treatment for tension-Type or cervicogenic headache: A systematic review and meta-Analysis of randomized, placebo-controlled trials 

      Roland, Sissel Breivold; Pripp, Are Hugo; Msomphora, Mbachi Ruth; Kvarstein, Gunnvald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-07)
      Objectives - The pathogeneses of chronic tension-type headache (CTTH) and cervicogenic headache (CEH) are not well established. Peripheral activation or sensitization of myofascial nociceptors is suggested as a potential mechanism and injections of botulinum toxin (BONTA) have thus been used in the treatment for both headache conditions. BONTA inhibits the release of acetylcholine at the neuromuscular ...
    • Electrosurgery and temperature increase in tissue with a passive metal implant 

      Martinsen, Tormod; Pettersen, Fred-Johan; Kalvøy, Håvard; Tronstad, Christian; Kvarstein, Gunnvald; Bakken, André; Høgetveit, Jan Olav; Martinsen, Ørjan Grøttem; Grimnes, Sverre; Frich, Lars Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-12)
      <i>Importance</i>: During monopolar electrosurgery in patients, current paths can be influenced by metal implants, which can cause unintentional tissue heating in proximity to implants. Guidelines concerning electrosurgery and active implants such as pacemakers or implantable cardioverter defibrillators have been published, but most describe interference between electrosurgery and the active implant ...
    • Health Related Quality of life in Adolescents with Chronic Fatigue Syndrome: A Cross-sectional Study 

      Winger, Anette; Kvarstein, Gunnvald; Wyller, Vegard Bruun; Ekstedt, Mirjam; Sulheim, Dag; Fagermoen, Frode Even; Småstuen, Milada C; Helseth, Sølvi (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-03)
      Aim: To study health related quality of life (HRQOL) and depressive symptoms in adolescents with chronic fatigue syndrome (CFS) and to investigate in which domains their HRQOL and depressive symptoms differ from those of healthy adolescents. <br>Background and objective: Several symptoms such as disabling fatigue, pain and depressive symptoms affect different life domains of adolescents with ...
    • Home administration of needle injections for children with rheumatic diseases: A qualitative study on nurses’ perception of their educational role 

      Sørensen, Kari; Skirbekk, Helge; Kvarstein, Gunnvald; Wøien, Hilde (Journal article; Tidsskriftartikkel, 2022-04-28)
      <p><i>Purpose -</i> To explore nurses' perceptions of their educational role, pedagogical competence, and practice in teaching children with rheumatic diseases and their parents to manage subcutaneous injections at home. <p><i>Design and methods -</i> In this qualitative study, we used thematic analysis to analyze data from three focus groups with 14 nurses responsible for patient education at one ...
    • I don’t want to think about it: A qualitative study of children’s and parents’ experiences with regular needle injections at home 

      Sørensen, Kari; Skirbekk, Helge; Kvarstein, Gunnvald; Wøien, Hilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
      <i>Background</i> - Overall outcomes of pediatric rheumatic diseases (RD) have improved due to treatment with biologic agents and methotrexate. For many children, this treatment often entails regular needle injections. Pain and fear of needle injections are common in childhood, but how children and parents handle long-term needle injections at home has not been fully explored. This study aimed to ...
    • Mediators of pain and physical function in female and male patients with chronic pain 

      Danielsson, Lena Elsa; Kvarstein, Gunnvald; Bergvik, Svein (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-19)
      <i>Purpose</i>: Chronic pain is often multifactorial and accompanied by psychological distress, catastrophizing thoughts, reduced physical function, and socio-economic worries. In this explorative study, we investigated potential mediators in the relationships of psychological and demographic variables with chronic pain and physical function in women and men.<p><p> <i>Patients and Methods</i>: ...
    • An observational post-authorization safety study (PASS) of naloxegol drug utilization in four European countries 

      Kvarstein, Gunnvald; Kindlundh-Högberg, Anna MS; Ould Setti, Mounir; Namane, Rafik; Muzwidzwa, Ruvimbo; Richter, Hartmut; Hakkarainen, Katja M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-15)
      Purpose - Naloxegol has been shown to be an efficient alternative to treat opioid-induced constipation (OIC). This study aimed at describing the characteristics of naloxegol users and assessing patterns of naloxegol use and associated factors.<p> <p>Methods - This drug utilization cohort study used observational registry data on patients newly prescribed naloxegol in four European countries. ...
    • Pain and pressure pain thresholds in adolescents With chronic fatigue syndrome and healthy Controls: a cross-sectional study 

      Winger, Anette; Kvarstein, Gunnvald; Wyller, Vegard Bruun; Sulheim, Dag; Fagermoen, Frode Even; Småstuen, Milada Cvancarova; Helseth, Sølvi (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-10-06)
      Objectives<br> Although pain is a significant symptom in chronic fatigue syndrome (CFS), pain is poorly understood in adolescents with CFS. The aim of this study was to explore pain distribution and prevalence, pain intensity and its functional interference in everyday life, as well as pressure pain thresholds (PPT) in adolescents with CFS and compare this with a control group of healthy adolescents ...
    • Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice 

      Hansson, Per; Jensen, Troels Staehelin; Kvarstein, Gunnvald; Strömberg, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)
      <p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...
    • Postoperative opioids and risk of respiratory depression - A cross-sectional evaluation of routines for administration and monitoring in a tertiary hospital 

      Andersen, Karoline Kolås; Kvarstein, Gunnvald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
      Objectives<p> Opioids are the most potent analgesics in the treatment of postoperative pain. Respiratory depression is, however, a serious side effect. The aims of this study were to evaluate current practice and routines for post-operative administration of opioids in a Norwegian university hospital and to evaluate whether the clinical safeguards adequately protected patients’ safety regarding risk ...
    • Recruitment and inclusion procedures as "pain killers" in clinical trials? 

      Nothnagel, Helen; Brown Menard, Martha; Kvarstein, Gunnvald; Norheim, Arne Johan; Weiss, Thomas; Puta, Christian; Mist, Scott D; Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-03)
      <p><i>Background - </i>Recruitment and inclusion procedures in clinical trials are time critical. This holds particularly true for studies investigating patients with fluctuating symptom patterns, like those with chronic neck pain. In a feasibility study on neck pain, we found a clinically relevant decrease in pain ratings within the recruitment period. This paper analyses the phenomenon and gives ...
    • Responses after spinal interventions in a clinical pain practice - A pragmatic observational study 

      Måwe, Leif; Thorén, Lena Måwe; Kvarstein, Gunnvald (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-24)
      Introduction - There is limited evidence for effect of interventional treatment, and pragmatic studies are needed to assess these interventions within a clinical setting. The aim of this study was to describe patients referred to an interventional pain clinic and investigate responses after spinal intervention in general and for radiofrequency ablation (RFA) and transforaminal epidural corticosteroid ...
    • Rettighetsvurdering og kvalitet på henvisninger - grad av samsvar mellom fire smertesentre 

      Stedenfeldt, Mona; Kvarstein, Gunnvald; Schjødt, Borrik; Johansen, Aslak; Berntsen, Anne Gina Schie; Brautaset, Astrid; Halsteinli, Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
      <p><i>BAKGRUNN - </i>Langvarige smerter er et utbredt helseproblem. De fire regionale tverrfaglige smertesentrene i Norge mottar årlig ca. 5 000 henvisninger fra fastleger og spesialisthelsetjenesten. Et likeverdig tilbud tilsier at henvisninger bør vurderes likt. Formålet med studien var å evaluere grad av samsvar mellom smertesentrenes inntaksteam i vurdering av kvalitet på mottatte henvisninger ...
    • Understanding Pain and Pain Management in Elderly Nursing Home Patients Applying an Interprofessional Learning Activity in Health Care Students: A Norwegian Pilot Study 

      Damsgård, Elin; Solgård, Hege; Johannessen, Karin; Wennevold, Katrine; Kvarstein, Gunnvald; Pettersen, Gunn; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-18)
      <p><i>Background - </i>Pain is common among elderly patients in nursing homes. However, pain assessment and treatment are inadequate. Interprofessional treatment is recommended, and consequently interprofessional education in pain management is necessary. <p><i>Aims - </i>This pilot project aimed to describe how two interprofessional groups of students approached pain management in two nursing ...